Multiple Sclerosis: Changes Beyond Demyelination Multiple Sclerosis: Changes Beyond Demyelination Multiple sclerosis (MS) is an autoimmune disease characterized by destruction of the myelin sheath surrounding the axons of the central nervous system. The damaged oligodendrocytes which generate myelin cannot be restored. Scarring occurs, which results in an interruption of the salutatory conduction of an action potential down the axon. This slower conduction velocity results in weakness and lack of coordination in the individual suffering from …showed first 75 words of 1474 total…

…showed last 75 words of 1474 total…Baltimore, MD: Lippincott, Williams & Wilkins. Evangelou, N., Konz, D., Esiri, M. M., Palace, J., & Matthews, P. M. (2000). Regional axonal loss in the corpus callosum correlates with cerebral white matter lesion volume and distribution in multiple sclerosis. Brain, 123, 1845-1849. Ge, Y., Grossman, R. I., Udupa, J. K., Babb, J. S., Nyul, L. G., & Kolson, D. L. (2001). Brain atrophy in relapsing-remitting multiple sclerosis: Fractional volumetric analysis of gray matter and white matter. Neuroradiology, 220, 606-611.